In present study formulation and evaluation of polyherbal wound healing gel by using selected plant extracts reported to possess antibacterial and antinflammatory activities like Curcuma longa, Plumbago zeylenica and Aloe barbadensis with sodium CMC as a gel forming polymer. The individual herbs were evaluated for their standard specification according to the WHO guideline and Ayurvedic Pharmacopeia of India. Extract were obtained by established procedures. Standardization of the extracts was done. Phytochemical test and TLC fingerprinting of the extracts was carried out for identification and confirmation of some known active constituent present in the herbs. The gel was prepared by using accurately weighed amount of extracts along with additives. All the prepared gel formulations were subjected for preliminary evaluation such as appearance, pH, viscosity and spreadability. All the selected plant material was found to be within the pharmacopoeial limits. Preliminary phytochemical analysis and TLC fingerprinting studies confirmed the presence of reported bioactive constituent, all the extracts were found to contain fairly good content of phenolics and extract proved to possess wound healing activity. From the formulation studies it was clearly evident that both gel formulations showed good gelling property and homogeneity. The pH of all formulation was in the range of 6-7.5 which lies in the normal pH range of skin. The obtained results of wound healing activity of formulation were encouraging, formulation A produced better wound healing activity than formulation B.100% wound closure was observed by the 14th post wound day in both gel formulations, formulation A of the extract and the standard. The developed formulation A proved to be beneficial in the treatment of wound healing.
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